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VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema.

Abstract:

Although lymphedema is a common clinical condition, treatment for this disabling condition remains limited and largely ineffective. Recently, it has been reported that overexpression of VEGF-C correlates with increased lymphatic vessel growth (lymphangiogenesis). However, the effect of VEGF-C-induced lymphangiogenesis on lymphedema has yet to be demonstrated. Here we investigated the impact of local transfer of naked plasmid DNA encoding human VEGF-C (phVEGF-C) on two animal models of lymphed...

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Publication status:
Published

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Publisher copy:
10.1172/jci15830

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Journal:
The Journal of clinical investigation
Volume:
111
Issue:
5
Pages:
717-725
Publication date:
2003-03-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:49bc8101-649f-44b8-ab3e-6a5965348d66
Source identifiers:
102522
Local pid:
pubs:102522

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