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Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation.

Abstract:

Eukaryotic initiation factor 2B (eIF2B) is the guanine nucleotide exchange factor for eIF2 and a critical regulator of protein synthesis, (e.g., as part of the integrated stress response). Certain mutations in the EIF2B genes cause leukoencephalopathy with vanishing white matter (VWM), an often serious neurological disorder. Comprising 5 subunits, α-ε (eIF2Bε being the catalytic one), eIF2B has always been considered an αβγδε heteropentamer. We have analyzed the subunit interactions within ma...

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Publication status:
Published

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Publisher copy:
10.1096/fj.13-243329

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Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume:
28
Issue:
5
Pages:
2225-2237
Publication date:
2014-05-05
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
URN:
uuid:49b7d13a-80f8-4c63-9504-5b03fc49a4e1
Source identifiers:
468300
Local pid:
pubs:468300

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