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Rhomboids: 7 years of a new protease family.

Abstract:
Drosophila Rhomboid-1 was discovered to be the first known intramembrane serine protease about 7 years ago. The study of the rhomboid-like family has since blossomed, and the purpose of this review is to take stock of where the field is, and how it may progress in the next few years. Three major themes are the increasing understanding of the biological roles of rhomboids, the detailed information we now have about their function and mechanism, and the promising leads they offer as medical targets.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Seminars in cell and developmental biology
Volume:
20
Issue:
2
Pages:
231-239
Publication date:
2009-04-05
DOI:
EISSN:
1096-3634
ISSN:
1084-9521
URN:
uuid:49b68fd6-5d63-448a-a63d-9a16e0e0c56b
Source identifiers:
356048
Local pid:
pubs:356048

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