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Synonymous codon usage influences the local protein structure observed

Abstract:

Translation of mRNA into protein is a unidirectional information flow process. Analysing the input (mRNA) and output (protein) of translation, we find that local protein structure information is encoded in the mRNA nucleotide sequence. The Coding Sequence and Structure (CSandS) database developed in this work provides a detailed mapping between over 4000 solved protein structures and their mRNA. CSandS facilitates a comprehensive analysis of codon usage over many organisms. In assigning trans...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkq495

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Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Statistics
More by this author
Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Statistics
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
38
Issue:
19
Pages:
6719-6728
Publication date:
2010
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:49b17980-6e6e-4d15-a977-7bc78a063824
Local pid:
ora:6013
Language:
English
Subjects:

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