Improved tumor targeting with chemically cross-linked recombinant antibody fragments.

Journal article

The construction and use of recombinant chimeric and later fully humanized (CDR-grafted) antibodies to tumor-associated antigens has reduced the immune response generated to these antibodies in clinical studies. However, their long circulating half-life is a disadvantage for tumor imaging and therapy. Fragments such as F(ab')2, Fab', Fv and single chain Fv (scFv) offer faster blood clearance but also lower overall tumor doses. We have examined the tumor targeting of several novel fragments pr...

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Authors: King, D; Turner, A; Farnsworth, A; Adair, JR; Owens, R

• Publication status: Published
• Journal: Cancer research
• Volume: 54
• Issue: 23
• Pages: 6176-6185
• Publication date: 1994-12-01
• EISSN: 1538-7445
• ISSN: 0008-5472
• Language: English
• Keywords: Cattle; Immunoglobulin Fragments; Cricetinae; Mice; Neoplasms, Experimental; CHO Cells; Yttrium Radioisotopes; Neoplasm Transplantation; Radioimmunotherapy; Immunoglobulin Fab Fragments; Mice, Nude; Animals; Recombinant Proteins; Transplantation, Heterologous