- Abstract:
-
To investigate the antigen specificity of regulatory T cells capable of preventing transplant rejection, we have developed two different strategies to achieve tolerance to fully mismatched skin grafts in euthymic mice. A combination of nondepleting Abs targeting CD4, CD8, and CD154 (CD40 ligand) induces dominant transplantation tolerance to fully mismatched skin allografts. Such tolerance is antigen-specific, mediated by regulatory T cells, and can be extended through linked suppression to na...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.0400084101
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 101
- Issue:
- 27
- Pages:
- 10122-10126
- Publication date:
- 2004-07-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:498dfd31-64bd-4d6b-b4ad-c9c62efffcfc
- Source identifiers:
-
2444
- Local pid:
- pubs:2444
- Copyright date:
- 2004
Journal article
Donor-specific transplantation tolerance: the paradoxical behavior of CD4+CD25+ T cells.
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