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The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to severe psoriatic arthritis: the 3-arm parallel group SPEED randomized controlled trial

Abstract:

Objectives: The aim of the Severe Psoriatic arthritis – Early intervEntion to control Disease trial is to compare outcomes in psoriatic arthritis (PsA) patients with poor prognostic factors treated with standard step-up conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), combination csDMARDs or a course of early biologics.

Design: This multicentre UK trial was embedded within the MONITOR-PsA cohort, which uses a trial within c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1177/1759720X241240913

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
ORCID:
0000-0001-8570-2113
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
ORCID:
0000-0003-3205-6706
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Publisher:
SAGE Publications
Journal:
Therapeutic Advances in Musculoskeletal Disease More from this journal
Volume:
16
Pages:
1-13
Publication date:
2024-05-30
Acceptance date:
2024-03-04
DOI:
EISSN:
1759-7218
ISSN:
1759-720X
Language:
English
Keywords:
Pubs id:
1742615
Local pid:
pubs:1742615
Deposit date:
2024-03-05

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