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Preparation and characterization of negatively charged poly(lactic-co-glycolic acid) microspheres.

Abstract:

Negatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres encapsulated with hydrophilic drugs have been successfully prepared by a solid-in-oil-in-water (s/o/w) solvent evaporation method in the presence of anionic surfactants, sodium dodecyl sulfate (SDS), and dioctyl sodium sulfosuccinate (DSS), and nonionic surfactant polyvinyl alcohol (PVA). The effects of microencapsulation methods, surfactants types, and surfactant concentrations on the properties of microspheres were studied...

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Publication status:
Published

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Publisher copy:
10.1002/jps.21612

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Materials
Czernuszka, J More by this author
Journal:
Journal of pharmaceutical sciences
Volume:
98
Issue:
7
Pages:
2377-2389
Publication date:
2009-07-05
DOI:
EISSN:
1520-6017
ISSN:
0022-3549
URN:
uuid:498b980a-4da9-4e97-92a6-8f3fdcc524b9
Source identifiers:
172961
Local pid:
pubs:172961

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