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Journal article

Combinatorial RNA splicing alters the surface charge on the NMDA receptor.

Abstract:
Transcripts encoding four NMDA receptor subunits, generated from the NMDAR1 gene by alternative RNA splicing, have been demonstrated in adult rat brain. RNA transcripts derived from cDNAs encoding each form direct the formation of functional NMDA receptors in Xenopus oocytes. The two amino acid cassettes of 21 and 37 amino acids found in the splice variants increase the positive extracellular surface charge on the subunits and may thereby modulate the functional properties of the receptor.
Publication status:
Published

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Authors


Anantharam, V More by this author
Panchal, RG More by this author
Kolchine, VV More by this author
Treistman, SN More by this author
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Journal:
FEBS letters
Volume:
305
Issue:
1
Pages:
27-30
Publication date:
1992-06-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:497b0066-466b-4591-8329-89743fe9936c
Source identifiers:
52218
Local pid:
pubs:52218

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