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Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2

Abstract:

The Polycomb repressive complexes PRC1 and PRC2 play a central role in developmental gene regulation in multicellular organisms. PRC1 and PRC2 modify chromatin by catalysing histone H2A lysine 119 ubiquitylation (H2AK119u1), and H3 lysine 27 methylation (H3K27me3), respectively. Reciprocal crosstalk between these modifications is critical for the formation of stable Polycomb domains at target gene loci. While the molecular mechanism for recognition of H3K27me3 by PRC1 is well defined, the int...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms13661

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Department:
Oxford, MSD, Biochemistry
Grijzenhout, A More by this author
Underwood, E More by this author
Ancelin, K More by this author
More by this author
Department:
Oxford, MSD, Biochemistry
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Danish Cancer Society More from this funder
Lundbeck Foundation More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
7
Pages:
Article: 13661
Publication date:
2016
Acceptance date:
2016-10-21
DOI:
ISSN:
2041-1723
Pubs id:
pubs:657370
URN:
uri:497988c5-2057-4aaa-bd05-9d84fcd25ac5
UUID:
uuid:497988c5-2057-4aaa-bd05-9d84fcd25ac5
Local pid:
pubs:657370

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