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The behavioral effects of heptyl physostigmine, a new cholinesterase inhibitor, in tests of long-term and working memory in rodents.

Abstract:

We assessed the effects of heptyl physostigmine, a new cholinesterase inhibitor, in a mouse tail-flick (TF) test, a mouse and rat passive avoidance test, a rat conditioned suppression-of-drinking (CSD) test, a rat Random Interval (RI) response rate test and a rat delayed matching-to-position (DMTP) test. In the TF test, a dose of 8.0 mg/kg of heptyl induced a significant antinociceptive effect that was in excess of 75% of the maximum possible effect 300 minutes after administration. In the mo...

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Publication status:
Published

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Authors


Dawson, GR More by this author
Bentley, G More by this author
Rycroft, W More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
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Journal:
Pharmacology, biochemistry, and behavior
Volume:
39
Issue:
4
Pages:
865-871
Publication date:
1991-08-05
DOI:
EISSN:
1873-5177
ISSN:
0091-3057
URN:
uuid:4979381c-cb60-4d1c-99a0-307701be60a8
Source identifiers:
29043
Local pid:
pubs:29043

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