Journal article
Development of a novel high-throughput assay for the investigation of GlyT-1b neurotransmitter transporter function.
- Abstract:
-
The glycine transporter (GlyT-1b) is a Na(+)/Cl(-)-dependent electrogenic transporter which mediates the rapid re-uptake of glycine from the synaptic cleft. Based on its tissue distribution, GlyT-1 has been suggested to co-localise with the NMDA receptor where it may modulate the concentration of glycine at its co-agonist binding site. This data has led to GlyT-1 inhibitors being proposed as targets for disorders such as schizophrenia and cognitive dysfunction. Radiolabelled uptake assays (e....
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- Publication status:
- Published
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- Publisher copy:
- 10.2174/138620706775213886
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Bibliographic Details
- Journal:
- Combinatorial chemistry and high throughput screening
- Volume:
- 9
- Issue:
- 1
- Pages:
- 9-14
- Publication date:
- 2006-01-01
- DOI:
- EISSN:
-
1875-5402
- ISSN:
-
1386-2073
- Source identifiers:
-
440029
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:440029
- UUID:
-
uuid:4970424f-7988-45a5-b618-7e49b4ef3af0
- Local pid:
- pubs:440029
- Deposit date:
- 2013-12-13
Terms of use
- Copyright date:
- 2006
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