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Development of a novel high-throughput assay for the investigation of GlyT-1b neurotransmitter transporter function.

Abstract:

The glycine transporter (GlyT-1b) is a Na(+)/Cl(-)-dependent electrogenic transporter which mediates the rapid re-uptake of glycine from the synaptic cleft. Based on its tissue distribution, GlyT-1 has been suggested to co-localise with the NMDA receptor where it may modulate the concentration of glycine at its co-agonist binding site. This data has led to GlyT-1 inhibitors being proposed as targets for disorders such as schizophrenia and cognitive dysfunction. Radiolabelled uptake assays (e....

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Publication status:
Published

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Publisher copy:
10.2174/138620706775213886

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Combinatorial chemistry and high throughput screening
Volume:
9
Issue:
1
Pages:
9-14
Publication date:
2006-01-05
DOI:
EISSN:
1875-5402
ISSN:
1386-2073
URN:
uuid:4970424f-7988-45a5-b618-7e49b4ef3af0
Source identifiers:
440029
Local pid:
pubs:440029

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