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Human SNM1a and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair

Abstract:

One of the major DNA interstrand cross-link (ICL) repair pathways in mammalian cells is coupled to replication, but the mechanistic roles of the critical factors involved remain largely elusive. Here, we show that purified human SNM1A (hSNM1A), which exhibits a 59-39 exonuclease activity, can load from a single DNA nick and digest past an ICL on its substrate strand. hSNM1A-depleted cells are ICL-sensitive and accumulate replicationassociated DNA double-strand breaks (DSBs), akin to ERCC1-dep...

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Publisher copy:
10.1101/gad.15699211

Authors


Sengerová, B More by this author
Cattell, E More by this author
Inagawa, T More by this author
Hartley, JM More by this author
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Journal:
Genes and Development
Volume:
25
Issue:
17
Pages:
1859-1870
Publication date:
2011-09-01
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
URN:
uuid:4967610f-b39f-4b25-be42-c7e5ddb0fd42
Source identifiers:
179743
Local pid:
pubs:179743

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