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Placental stress and pre-eclampsia: a revised view.

Abstract:

In pre-eclampsia, poor placentation causes both oxidative and endoplasmic reticulum stress of the placenta. It is believed placental hypoxia stimulates excessive production of soluble fms-like tyrosine kinase 1 (sFlt-1), which binds and deactivates circulating vascular endothelial growth factor (VEGF). When maternal endothelium is deprived of VEGF it becomes dysfunctional hence leading to the clinical syndrome of the mother. In this paper the previous claim that poor placentation may predispo...

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Publication status:
Published

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Authors


Redman, CW More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Journal:
Placenta
Volume:
30 Suppl A
Issue:
SUPPL.
Pages:
S38-S42
Publication date:
2009-03-05
DOI:
EISSN:
1532-3102
ISSN:
0143-4004
URN:
uuid:494ff604-2d41-4710-8a5b-904e0fb6ae28
Source identifiers:
248241
Local pid:
pubs:248241

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