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The causal roles of vitamin B(12) and transcobalamin in prostate cancer: can Mendelian randomization analysis provide definitive answers?

Abstract:

Circulating vitamin B(12) (cobalamin/B(12)) and total transcobalamin (tTC) have been associated with increased and reduced risk, respectively, of prostate cancer. Mendelian randomization has the potential to determine whether these are causal associations. We estimated associations of single nucleotide polymorphisms in B(12)-related genes (MTR, MTRR, FUT2, TCN2, TCN1, CUBN, and MUT) with plasma concentrations of B(12), tTC, holo-transcobalamin, holo-haptocorrin, folate, and homocysteine and w...

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Journal:
International journal of molecular epidemiology and genetics
Volume:
2
Issue:
4
Pages:
316-327
Publication date:
2011-01-01
EISSN:
1948-1756
URN:
uuid:494cabe7-891b-40d0-b75b-120e6d297224
Source identifiers:
222339
Local pid:
pubs:222339

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