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Acute changes of myocardial creatine kinase gene expression under beta-adrenergic stimulation.

Abstract:

Creatine kinase (CK) plays a crucial role in myocardial energy metabolism. Alterations in CK gene expression are found in hypertrophied and failing heart, but the mechanisms behind these changes are unclear. This study tests the hypothesis that increased adrenergic stimulation, which is observed in heart failure, induces changes of myocardial CK-activity, -isoenzyme distribution and -gene expression that are characteristic of the failing and hypertrophied heart. Isolated rat hearts were perfu...

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Publication status:
Published

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Journal:
Biochimica et biophysica acta
Volume:
1502
Issue:
3
Pages:
471-480
Publication date:
2000-11-01
DOI:
ISSN:
0006-3002
Source identifiers:
124828
Language:
English
Keywords:
Pubs id:
pubs:124828
UUID:
uuid:493ae95b-905b-40c7-922e-00f1c50fca89
Local pid:
pubs:124828
Deposit date:
2012-12-19

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