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First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase

Abstract:
We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP5 mimics 5-PP-InsP 5 binding to the kinase domain of PPIP5K2; both molecules were phosphorylated by the enzyme. PA-InsPs are promising candidates for further studies into the biology of PP-InsPs.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1039/c2cc36044f

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Department:
Oxford, MSD, Pharmacology
Weaver, JD More by this author
Shears, SB More by this author
Potter, BVL More by this author
Wellcome Trust More from this funder
Intramural NIH HHS More from this funder
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Chemical Communications Journal website
Volume:
48
Issue:
92
Pages:
11292-11294
Publication date:
2012-09-14
Acceptance date:
2012-08-20
DOI:
ISSN:
1364-548X and 1359-7345
Pubs id:
pubs:640299
URN:
uri:492aff60-2843-4c0c-ba7e-d490c6b7f8b2
UUID:
492aff60-2843-4c0c-ba7e-d490c6b7f8b2
Local pid:
pubs:640299

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