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First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase

Abstract:
We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP5 mimics 5-PP-InsP 5 binding to the kinase domain of PPIP5K2; both molecules were phosphorylated by the enzyme. PA-InsPs are promising candidates for further studies into the biology of PP-InsPs.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1039/c2cc36044f

Authors


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Department:
Oxford, MSD, Pharmacology
Role:
Author
Wellcome Trust More from this funder
Intramural NIH HHS More from this funder
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Chemical Communications Journal website
Volume:
48
Issue:
92
Pages:
11292-11294
Publication date:
2012-09-14
Acceptance date:
2012-08-20
DOI:
ISSN:
1364-548X and 1359-7345
Pubs id:
pubs:640299
URN:
uri:492aff60-2843-4c0c-ba7e-d490c6b7f8b2
UUID:
492aff60-2843-4c0c-ba7e-d490c6b7f8b2
Local pid:
pubs:640299
Paper number:
92

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