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Aggregation of model membrane proteins, modulated by hydrophobic mismatch, membrane curvature, and protein class

Abstract:

Aggregation of transmembrane proteins is important for many biological processes, such as protein sorting and cell signaling, and also for in vitro processes such as two-dimensional crystallization. We have used large-scale simulations to study the lateral organization and dynamics of lipid bilayers containing multiple inserted proteins. Using coarse-grained molecular dynamics simulations, we have studied model membranes comprising ∼7000 lipids and 16 identical copies of model cylindrical pro...

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Publisher copy:
10.1016/j.bpj.2011.06.048

Authors


Parton, DL More by this author
Klingelhoefer, JW More by this author
Sansom, MSP More by this author
Journal:
Biophysical Journal
Volume:
101
Issue:
3
Pages:
691-699
Publication date:
2011-08-03
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:492a5036-7adb-4725-9b67-b417227f4940
Source identifiers:
179780
Local pid:
pubs:179780
Language:
English

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