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How do pathogens drive the evolution of paired receptors?

Abstract:

Paired receptors are families of membrane proteins characterized by similar extracellular regions but different transmembrane and cytoplasmic regions, meaning that some members can give inhibitory signals and others activating signals. Well-characterized examples include the KIR, SIRP, Ly49, Nkpr, and Siglec families. The difference in the repertoire of these genes in mouse and man indicates that these families have evolved rapidly. For example, KIRs are found in humans and not mice, and Ly49...

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Publisher copy:
10.1002/eji.201242896

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
European journal of immunology
Volume:
43
Issue:
2
Pages:
303-313
Publication date:
2013-02-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:4925bb07-f913-4efb-9845-3c2204141f9b
Source identifiers:
369919
Local pid:
pubs:369919

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