Journal article
FANCD2 limits replication stress and genome instability in cells lacking BRCA2.
- Abstract:
- The tumor suppressor BRCA2 plays a key role in genome integrity by promoting replication fork stability and homologous recombination (HR) DNA repair. Here we report that human cancer cells lacking BRCA2 rely on the Fanconi anemia protein FANCD2 to limit replication fork progression and genomic instability. Our results identify a novel role for FANCD2 in limiting constitutive replication stress in BRCA2-deficient cells, which impacts on cell survival and treatment responses.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 7.2MB, Terms of use)
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- Publisher copy:
- 10.1038/nsmb.3252
Authors
- Publisher:
- Nature Publishing Group
- Journal:
- Nature Structural and Molecular Biology More from this journal
- Volume:
- 23
- Pages:
- 755-757
- Publication date:
- 2016-06-20
- Acceptance date:
- 2016-06-07
- DOI:
- EISSN:
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1545-9985
- ISSN:
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1545-9993
- Language:
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English
- Pubs id:
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pubs:631056
- UUID:
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uuid:49140ae9-3f26-44e0-b31d-418563d5c80f
- Local pid:
-
pubs:631056
- Source identifiers:
-
631056
- Deposit date:
-
2016-07-12
Terms of use
- Copyright holder:
- © 2016 Nature America, Inc All rights reserved
- Copyright date:
- 2016
- Notes:
- © 2016 Nature America, Inc. All rights reserved. This is the author accepted manuscript following peer review version of the article. The final version is available online from Nature Publishing Group at: 10.1038/nsmb.3252
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