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Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.

Abstract:

The SIN3A-HDAC complex deacetylates histones thereby repressing gene transcription. Here we describe family with sequence similarity 60A (FAM60A), a cell cycle-regulated protein that binds to the SIN3-HDAC complex. FAM60A expression peaks during G(1) and S phases of the cell cycle in U2OS cells, in a manner similar to the G(1) regulator cyclin D1, which is a known target of SIN3-HDAC. In this light we found that FAM60A binds to SIN3-HDAC-regulated promoters such as cyclin D1 in G(1) and S pha...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m112.382499

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Journal:
The Journal of biological chemistry
Volume:
287
Issue:
39
Pages:
32346-32353
Publication date:
2012-09-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:49120a34-85e1-4a21-8a63-458669a70f23
Source identifiers:
345718
Local pid:
pubs:345718

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