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Pharmacokinetics of amodiaquine and desethylamodiaquine in pregnant and postpartum women with Plasmodium vivax malaria.

Abstract:

In order to study the pharmacokinetic properties of amodiaquine and desethylamodiaquine during pregnancy, 24 pregnant women in the second and third trimesters of pregnancy and with Plasmodium vivax malaria were treated with amodiaquine (10 mg/kg of body weight/day) for 3 days. The same women were studied again at 3 months postpartum. Plasma was analyzed for amodiaquine and desethylamodiaquine by use of a liquid chromatography-tandem mass spectrometry method. Individual concentration-time data...

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Publication status:
Published

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Publisher copy:
10.1128/aac.00154-11

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
55
Issue:
9
Pages:
4338-4342
Publication date:
2011-09-01
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Source identifiers:
163940
Language:
English
Keywords:
Pubs id:
pubs:163940
UUID:
uuid:49108f9c-6fcb-4f2e-a99e-9e5f2b230364
Local pid:
pubs:163940
Deposit date:
2012-12-19

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