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An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration.

Abstract:

The sequestration of parasitized erythrocytes in the microvasculature of vital organs is central to the pathogenesis of severe Plasmodium falciparum malaria. This process is mediated by specific interactions between parasite adherence ligands and host receptors on vascular endothelium such as intercellular adhesion molecule-1 (ICAM-1) and CD36. Using immunohistochemistry we have examined the distribution of putative sequestration receptors in different organs from fatal cases of P. falciparum...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Morrison, H More by this author
Looareesuwan, S More by this author
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Journal:
The American journal of pathology
Volume:
145
Issue:
5
Pages:
1057-1069
Publication date:
1994-11-05
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:48f568b5-b44a-43ce-b1a0-28cea2ede327
Source identifiers:
23476
Local pid:
pubs:23476

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