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Measurement of plasma 5-hydroxyindoleacetic acid as a possible clinical surrogate marker for the action of antivascular agents.

Abstract:

BACKGROUND: Serotonin (5HT), a naturally occurring vasoactive substance, is released from platelets into plasma under various pathological conditions. Recently, anticancer drugs that act by selectively disrupting tumour blood flow have been found to increase plasma 5HT concentrations in mice. Two such antivascular agents, flavone acetic acid (FAA) and 5,6-dimethylxanthenone-4-acetic acid (DMXAA), have completed Phase I clinical trial and raise the important question of whether suitable surrog...

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Publication status:
Published

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Authors


Kestell, P More by this author
Jameson, MB More by this author
Stratford, MR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Journal:
Clinica chimica acta; international journal of clinical chemistry
Volume:
314
Issue:
1-2
Pages:
159-166
Publication date:
2001-12-05
DOI:
EISSN:
1873-3492
ISSN:
0009-8981
URN:
uuid:48efa3db-9ef5-4c78-9478-73e2f6b6af87
Source identifiers:
131592
Local pid:
pubs:131592

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