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The Antiviral Efficacy of HIV-Specific CD8(+) T-Cells to a Conserved Epitope Is Heavily Dependent on the Infecting HIV-1 Isolate

Abstract:

A major challenge to developing a successful HIV vaccine is the vast diversity of viral sequences, yet it is generally assumed that an epitope conserved between different strains will be recognised by responding T-cells. We examined whether an invariant HLA-B8 restricted Nef90-97 epitope FL8 shared between five high titre viruses and eight recombinant vaccinia viruses expressing Nef from different viral isolates (clades A-H) could activate antiviral activity in FL8-specific cytotoxic T-lympho...

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Publication status:
Published

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Journal:
PLOS PATHOGENS
Volume:
7
Issue:
5
Publication date:
2011-05-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:48e7764b-1e3a-41b0-8f8f-1cbf6474cbfb
Source identifiers:
151311
Local pid:
pubs:151311
Language:
English

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