Journal article
IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3).
- Abstract:
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IGF-1 has been shown to promote proliferation of normal epithelial breast cells, and the IGF pathway has also been linked to mammary carcinogenesis in animal models. We comprehensively examined the association between common genetic variation in the IGF1, IGFBP1, and IGFBP3 genes in relation to circulating IGF-I and IGFBP-3 levels and breast cancer risk within the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). This analysis included 6,912 breast cancer cases and 8,891 matched contro...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 305.4KB)
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- Publisher copy:
- 10.1371/journal.pone.0002578
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Authors
Funding
National Cancer Institute
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National Institutes of Health
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 3
- Issue:
- 7
- Pages:
- e2578
- Publication date:
- 2008-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- Source identifiers:
-
66991
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:66991
- UUID:
-
uuid:48e688d0-4aa0-4962-9093-ab1bf6aa5014
- Local pid:
- pubs:66991
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Patel et al
- Copyright date:
- 2008
- Notes:
- Copyright 2008 Patel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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