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Journal article

The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages.

Abstract:

PURPOSE: Drusen, which are defined clinically as yellowish white spots in the outer retina, are cardinal features of age-related macular degeneration (AMD). Ccl2-knockout (Ccl2(-/-)) mice have been reported to develop drusen and phenotypic features similar to AMD, including an increased susceptibility to choroidal neovascularization (CNV). This study was conducted to investigate the nature of the drusenlike lesions in vivo and further evaluate the Ccl2(-/-) mouse as a model of AMD. METHODS: T...

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Publication status:
Published

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Publisher copy:
10.1167/iovs.09-3462

Authors


Luhmann, UF More by this author
Barker, SE More by this author
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Journal:
Investigative ophthalmology and visual science
Volume:
50
Issue:
12
Pages:
5934-5943
Publication date:
2009-12-05
DOI:
EISSN:
1552-5783
ISSN:
0146-0404
URN:
uuid:48d4dc4c-6975-4928-955a-d774dc753f40
Source identifiers:
107261
Local pid:
pubs:107261

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