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Cell-surface bound pertussis toxin induces polyclonal T cell responses with high levels of interferon-gamma in the absence of interleukin-12.

Abstract:

Pertussis toxin (PTx), an exotoxin produced by Bordetella pertussis, has long been used as a mucosal adjuvant. We examined the T cell stimulatory properties of PTx in order to dissect its mechanisms of adjuvanticity. PTx or the B-oligomer of PTx (PTxB) failed to activate purified murine CD4+ or CD8+ T cells, as measured by a lack of proliferation or expression of early T cell activation markers. However, these T cells proliferated extensively in response to the toxin in the presence of syngen...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200323675

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
European journal of immunology
Volume:
33
Issue:
7
Pages:
1859-1868
Publication date:
2003-07-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Source identifiers:
32386
Language:
English
Keywords:
Pubs id:
pubs:32386
UUID:
uuid:48d24bf1-2580-4474-b0d7-4feb7a2ed2b6
Local pid:
pubs:32386
Deposit date:
2012-12-19

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