Journal article icon

Journal article

Clinical and biological implications of driver mutations in myelodysplastic syndromes.

Abstract:

Myelodysplastic syndromes (MDS) are a heterogeneous group of chronic hematological malignancies characterized by dysplasia, ineffective hematopoiesis and a variable risk of progression to acute myeloid leukemia. Sequencing of MDS genomes has identified mutations in genes implicated in RNA splicing, DNA modification, chromatin regulation, and cell signaling. We sequenced 111 genes across 738 patients with MDS or closely related neoplasms (including chronic myelomonocytic leukemia and MDS-myelo...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Papaemmanuil, E More by this author
Gerstung, M More by this author
Malcovati, L More by this author
Expand authors...
Journal:
Blood
Volume:
122
Issue:
22
Pages:
3616-3699
Publication date:
2013-11-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:48d07695-72c4-4f49-83a3-c4ee347e4e98
Source identifiers:
429173
Local pid:
pubs:429173

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP