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A sister of NANOG regulates genes expressed in pre-implantation human development

Abstract:

The NANOG homeobox gene plays a pivotal role in self-renewal and maintenance of pluripotency in human, mouse and other vertebrate embryonic stem cells, and in pluripotent cells of the blastocyst inner cell mass. There is a poorly studied and atypical homeobox locus close to the Nanog gene in some mammals which could conceivably be a cryptic paralogue of NANOG, even though the loci share only 20% homeodomain identity. Here we argue that this gene, NANOGNB (NANOG Neighbour), is an extremely div...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1098/rsob.170027

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
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Institution:
University of Oxford
Department:
Merton College
Role:
Author
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Grant:
FP7/2007-2013 ERC grant 268513
EPA Cephalosporin Fund More from this funder
Publisher:
Royal Society Publisher's website
Journal:
Open Biology Journal website
Volume:
7
Issue:
4
Chapter number:
170027
Publication date:
2017-04-26
Acceptance date:
2017-04-03
DOI:
EISSN:
2046-2441
Pubs id:
pubs:687768
URN:
uri:48cb82f5-6e16-4dba-a5d2-a42e589962d0
UUID:
uuid:48cb82f5-6e16-4dba-a5d2-a42e589962d0
Local pid:
pubs:687768
Paper number:
4

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