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Risedronate in adults with osteogenesis imperfecta type I: increased bone mineral density and decreased bone turnover, but high fracture rate persists.

Abstract:

UNLABELLED: Bisphosphonates can increase bone mineral density (BMD) in children with osteogenesis imperfecta (OI). In this study of adults with OI type I, risedronate increased BMD at lumbar spine (but not total hip) and decreased bone turnover. However, the fracture rate in these patients remained high. INTRODUCTION: Intravenous bisphosphonates given to children with OI can increase BMD and reduce fracture incidence. Oral and/or intravenous bisphosphonates may have similar effects in adults...

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Publication status:
Published

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Publisher copy:
10.1007/s00198-011-1658-2

Authors


Bradbury, LA More by this author
Geoghegan, F More by this author
Hannon, RA More by this author
Stuckey, SL More by this author
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Journal:
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Volume:
23
Issue:
1
Pages:
285-294
Publication date:
2012-01-05
DOI:
EISSN:
1433-2965
ISSN:
0937-941X
URN:
uuid:48c9dd9c-ab17-4e8e-b091-06dfda3d3883
Source identifiers:
246069
Local pid:
pubs:246069

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