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Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease.

Abstract:

Excessive synchronisation of basal ganglia activity at frequencies < 30 Hz is a hallmark of the parkinsonian state, and may contribute to bradykinesia. Accordingly, we electrically stimulated chronically implanted subthalamic macroelectrodes in 10 Parkinson's disease patients, after overnight withdrawal of anti-parkinsonian medication. We compared the effects of stimulation at 0, 5, 10, 15, 20, 25, 30, and ca. 130 Hz by measuring kinesia time (KT) in a tapping task. Although the effects of...

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Publication status:
Published

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Journal:
Neuroscience letters
Volume:
382
Issue:
1-2
Pages:
5-9
Publication date:
2005-01-01
DOI:
EISSN:
1872-7972
ISSN:
0304-3940
URN:
uuid:48c54b71-0c92-47c3-a177-fbf177223f06
Source identifiers:
122448
Local pid:
pubs:122448

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