Journal article
Localised translation of gurken/TGF-α mRNA during axis specification is controlled by access to Orb/CPEB on Processing bodies
- Abstract:
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In Drosophila oocytes, gurken/TGF-α mRNA is essential for establishing the future embryonic axes. gurken remains translationally silent during transport from its point of synthesis in nurse cells to its final destination in the oocyte, where it associates with the edge of Processing bodies. Here, we show that, in nurse cells, gurken is kept translationally silent by the lack of sufficient Orb/CPEB, its translational activator. Processing bodies in nurse cells have a similar protein complement...
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- Publication status:
- In press
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 3.8MB)
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- Publisher copy:
- 10.1016/j.celrep.2016.02.038
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Authors
Funding
+ Wellcome Trust
More from this funder
Funding agency for:
Davis, I
Grant:
Senior Research Fellowship 096144
Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Cell Reports Journal website
- Publication date:
- 2016-03-15
- Acceptance date:
- 2016-02-03
- DOI:
- ISSN:
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2211-1247
- Source identifiers:
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604514
Item Description
- Pubs id:
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pubs:604514
- UUID:
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uuid:48c0182f-bf57-4f63-aa7b-3cb4c538173e
- Local pid:
- pubs:604514
- Deposit date:
- 2016-02-17
Terms of use
- Copyright holder:
- Davidson et al
- Copyright date:
- 2016
- Notes:
- ©2016 The Authors. This is the publisher's version of the article. The final version is available online from Elsevier (Cell Press) at: [10.1016/j.celrep.2016.02.038]
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