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Localised translation of gurken/TGF-α mRNA during axis specification is controlled by access to Orb/CPEB on Processing bodies

Abstract:

In Drosophila oocytes, gurken/TGF-α mRNA is essential for establishing the future embryonic axes. gurken remains translationally silent during transport from its point of synthesis in nurse cells to its final destination in the oocyte, where it associates with the edge of Processing bodies. Here, we show that, in nurse cells, gurken is kept translationally silent by the lack of sufficient Orb/CPEB, its translational activator. Processing bodies in nurse cells have a similar protein complement...

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Publication status:
In press
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2016.02.038

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Doctoral Training Centre - MPLS
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Funding agency for:
Davidson, A
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Funding agency for:
Parton, RM
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Funding agency for:
Davis, I
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Grant:
Strategic Awards 091911; 107457
Publisher:
Elsevier (Cell Press) Publisher's website
Journal:
Cell Reports Journal website
Publication date:
2016-03-15
DOI:
ISSN:
2211-1247
URN:
uuid:48c0182f-bf57-4f63-aa7b-3cb4c538173e
Source identifiers:
604514
Local pid:
pubs:604514

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