- Abstract:
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In Drosophila oocytes, gurken/TGF-α mRNA is essential for establishing the future embryonic axes. gurken remains translationally silent during transport from its point of synthesis in nurse cells to its final destination in the oocyte, where it associates with the edge of Processing bodies. Here, we show that, in nurse cells, gurken is kept translationally silent by the lack of sufficient Orb/CPEB, its translational activator. Processing bodies in nurse cells have a similar protein complement...
Expand abstract - Publication status:
- In press
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 3.8MB)
-
- Publisher copy:
- 10.1016/j.celrep.2016.02.038
-
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- Publisher:
- Elsevier (Cell Press) Publisher's website
- Journal:
- Cell Reports Journal website
- Publication date:
- 2016-03-15
- DOI:
- ISSN:
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2211-1247
- URN:
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uuid:48c0182f-bf57-4f63-aa7b-3cb4c538173e
- Source identifiers:
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604514
- Local pid:
- pubs:604514
- Copyright holder:
- Davidson et al.
- Copyright date:
- 2016
- Notes:
- ©2016 The Authors. This is the publisher's version of the article. The final version is available online from Elsevier (Cell Press) at: [10.1016/j.celrep.2016.02.038]
Journal article
Localised translation of gurken/TGF-α mRNA during axis specification is controlled by access to Orb/CPEB on Processing bodies
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