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Journal article

Localised translation of gurken/TGF-α mRNA during axis specification is controlled by access to Orb/CPEB on Processing bodies

Abstract:

In Drosophila oocytes, gurken/TGF-α mRNA is essential for establishing the future embryonic axes. gurken remains translationally silent during transport from its point of synthesis in nurse cells to its final destination in the oocyte, where it associates with the edge of Processing bodies. Here, we show that, in nurse cells, gurken is kept translationally silent by the lack of sufficient Orb/CPEB, its translational activator. Processing bodies in nurse cells have a similar protein complement...

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Publication status:
In press
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2016.02.038

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Funding agency for:
Davidson, A
Grant:
Studentship 097304
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Funding agency for:
Parton, R
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Funding agency for:
Davis, I
Grant:
Senior Research Fellowship 096144
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Grant:
Strategic Awards 091911; 107457
Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Publication date:
2016-03-15
Acceptance date:
2016-02-03
DOI:
ISSN:
2211-1247
Source identifiers:
604514
Pubs id:
pubs:604514
UUID:
uuid:48c0182f-bf57-4f63-aa7b-3cb4c538173e
Local pid:
pubs:604514
Deposit date:
2016-02-17

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