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Journal article

The role of basal and myogenic factors in the transcriptional activation of utrophin promoter A: implications for therapeutic up-regulation in Duchenne muscular dystrophy.

Abstract:

Duchenne muscular dystrophy (DMD) is an X-linked recessive muscle wasting disease caused by the absence of a muscle cytoskeletal protein, dystrophin. Utrophin is the autosomal homologue of dystrophin. We previously demonstrated that overexpression of utrophin in the muscles of dystrophin-null transgenic mice completely prevented the phenotype arising from dystrophin deficiency. Two independently regulated promoters control utrophin expression and the upstream promoter (promoter A) is synaptic...

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Publication status:
Published

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Publisher copy:
10.1093/nar/29.23.4843

Authors


Perkins, KJ More by this author
Burton, EA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Nucleic acids research
Volume:
29
Issue:
23
Pages:
4843-4850
Publication date:
2001-12-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:48ac228d-6523-4f6f-b486-b4d0869a2cc1
Source identifiers:
106555
Local pid:
pubs:106555

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