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Type 1 fimbriae and extracellular polysaccharides are preeminent uropathogenic Escherichia coli virulence determinants in the murine urinary tract.

Abstract:

Escherichia coli is the leading cause of urinary tract infections (UTIs). Despite the association of numerous bacterial factors with uropathogenic E. coli (UPEC), few such factors have been proved to be required for UTI in animal models. Previous investigations of urovirulence factors have relied on prior identification of phenotypic characteristics. We used signature-tagged mutagenesis (STM) in an unbiased effort to identify genes that are essential for UPEC survival within the murine urinar...

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Authors


Bahrani-Mougeot, FK More by this author
Buckles, EL More by this author
Lockatell, CV More by this author
Johnson, DE More by this author
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Journal:
Molecular microbiology
Volume:
45
Issue:
4
Pages:
1079-1093
Publication date:
2002-08-05
DOI:
EISSN:
1365-2958
ISSN:
0950-382X
URN:
uuid:489f2ad7-3540-4676-bcb1-94a24a230ce6
Source identifiers:
249507
Local pid:
pubs:249507

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