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Journal article

Harnessing FOXP3+ regulatory T cells for transplantation tolerance.

Abstract:
Early demonstrations that mice could be tolerized to transplanted tissues with short courses of immunosuppressive therapy and that with regard to tolerance to self, CD4+FOXP3+ regulatory T cells (Tregs) appeared to play a critical role, have catalyzed strategies to harness FOXP3-dependent processes to control rejection in human transplantation. This review seeks to examine the scientific underpinning for this new approach to finesse immunosuppression.
Publication status:
Published

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Publisher copy:
10.1172/jci67226

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Hilbrands, R More by this author
Cobbold, S More by this author
Publisher:
The American Society for Clinical Investigation
Journal:
The Journal of clinical investigation
Volume:
124
Issue:
4
Pages:
1439-1445
Publication date:
2014-04-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:489b681a-cfa7-47b1-9a0f-d69f48cea805
Source identifiers:
458779
Local pid:
pubs:458779

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