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Journal article

Chronic TNFα - driven injury delays cell migration to villi in the intestinal epithelium

Abstract:

The intestinal epithelium is a single layer of cells which provides the first line of defence of the intestinal mucosa to bacterial infection. Cohesion of this physical barrier is supported by renewal of epithelial stem cells, residing in invaginations called crypts, and by crypt cell migration onto protrusions called villi; dysregulation of such mechanisms may render the gut susceptible to chronic in ammation. The impact that excessive or misplaced epithelial cell death may have on villus ce...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1098/rsif.2018.0037

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Filippi, S More by this author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Fletcher, A More by this author
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Publisher:
Royal Society Publisher's website
Journal:
Interface Journal website
Volume:
15
Issue:
145
Pages:
Article: 20180037
Publication date:
2018-08-01
Acceptance date:
2018-07-03
DOI:
EISSN:
1742-5662
ISSN:
1742-5689
Pubs id:
pubs:864655
URN:
uri:487ede2f-9c04-4344-b4b7-3a153c68cecd
UUID:
uuid:487ede2f-9c04-4344-b4b7-3a153c68cecd
Local pid:
pubs:864655

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