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HIV reverse transcriptase structures: designing new inhibitors and understanding mechanisms of drug resistance.

Abstract:

HIV reverse transcriptase (RT) is one of the main targets for the action of anti-AIDS drugs. The selection of drug-resistant HIV is a key problem in the continued treatment of the infection and thus new drugs are required. A significant body of information consisting of HIV-1 RT crystal structures with bound inhibitors has become available during the past several years, and, increasingly, such data will be of use in developing novel inhibitors. Two examples of crystal structures of HIV-1 RT w...

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Publication status:
Published

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Publisher copy:
10.1016/j.tips.2004.11.003

Authors


Stammers, DK More by this author
Journal:
Trends in pharmacological sciences
Volume:
26
Issue:
1
Pages:
4-7
Publication date:
2005-01-05
DOI:
EISSN:
1873-3735
ISSN:
0165-6147
URN:
uuid:487d76af-e76c-4ca2-8fe8-6115f30e1d44
Source identifiers:
72625
Local pid:
pubs:72625

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