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A GFP-actin reporter line to explore microfilament dynamics across the malaria parasite lifecycle.

Abstract:

Malaria parasite motility relies on an internal parasite actomyosin motor that, when linked to the host cell substrate, propels motile zoites forward. Despite their key role in this process, attempts to visualize actin microfilaments (F-actin) during motility and under native microscopy conditions have not to date been successful. Towards facilitating their visualization we present here a Plasmodium berghei transgenic line in which a green fluorescent protein (GFP)-actin fusion is constitutiv...

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Authors


Angrisano, F More by this author
Delves, MJ More by this author
Mollard, V More by this author
McFadden, GI More by this author
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Journal:
Molecular and biochemical parasitology
Volume:
182
Issue:
1-2
Pages:
93-96
Publication date:
2012
DOI:
EISSN:
1872-9428
ISSN:
0166-6851
URN:
uuid:486dcd9d-ef02-49d8-8253-b17149b0dc0c
Source identifiers:
273122
Local pid:
pubs:273122

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