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Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.

Abstract:

Patients with established type 2 diabetes display both β-cell dysfunction and insulin resistance. To define fundamental processes leading to the diabetic state, we examined the relationship between type 2 diabetes risk variants at 37 established susceptibility loci, and indices of proinsulin processing, insulin secretion, and insulin sensitivity. We included data from up to 58,614 nondiabetic subjects with basal measures and 17,327 with dynamic measures. We used additive genetic models with a...

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Publication status:
Published

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Publisher copy:
10.2337/db13-0949

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Journal:
Diabetes
Volume:
63
Issue:
6
Pages:
2158-2171
Publication date:
2014-06-01
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Source identifiers:
441702

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