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Optimization by experimental design of precursor synthesis and radiolabeling of 2-iodo-L-phenylalanine, a novel amino acid for tumor imaging.

Abstract:

Various radiolabeled amino acids show promising results in tumor detection, as applied in the management of cancer patients. We synthesized the precursor 2-iodo-L-phenylalanine for easier kit labeling of [123/125I]- 2-iodo-L-phenylalanine, using the Cu1+ -assisted nucleophilic halogen exchange. Precursor synthesis was optimized by experimental design: Eight parameters were initially screened by a quarter fractional design. The resulting most important parameters (i.e., temperature, CuSO4, NaI...

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Publication status:
Published

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Publisher copy:
10.1089/cbr.2006.21.235

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
Cancer biotherapy and radiopharmaceuticals
Volume:
21
Issue:
3
Pages:
235-242
Publication date:
2006-06-05
DOI:
EISSN:
1557-8852
ISSN:
1084-9785
URN:
uuid:4854ad15-d7b0-47a8-8582-b32b744acf75
Source identifiers:
258443
Local pid:
pubs:258443

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