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An experimental medicine study of the effects of simvastatin on emotional processing, reward learning, verbal memory, and inflammation in healthy volunteers

Abstract:

Rationale Clinical studies suggest that the highly lipophilic, anti-inflammatory molecule, simvastatin, might be an ideal candidate for drug repurposing in the treatment of depression. The neuropsychological effects of simvastatin are not known, but their ascertainment would have significant translational value about simvastatin’s influence on mood and cognition. Objectives We aimed to investigate the effects of simvastatin on a battery of psychological tests and inflammatory markers in heal...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00213-022-06156-y

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Oxford college:
Brasenose College
Role:
Author
ORCID:
0000-0001-5984-8696
Publisher:
Springer
Journal:
Psychopharmacology More from this journal
Volume:
239
Pages:
2635-2645
Publication date:
2022-05-05
Acceptance date:
2022-04-22
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
Language:
English
Keywords:
Pubs id:
1253153
Local pid:
pubs:1253153
Deposit date:
2022-04-25

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