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Thesis

Studies of the DNA repair proteins FANCD2/FANCI and DNA polymerase eta

Abstract:

Our genome is continuously under various sources of genotoxic stresses. Thus, human has developed several DNA repair pathways to deal with different types of DNA damage. This thesis contains two studies, one focusing on the Fanconi Anemia pathway, which is known to coordinate the DNA interstrand crosslink repair, and the other one on the regulation of translesion synthesis, which is responsible for replication at DNA lesion sites, e.g. UV induced pyrimidine dimers.

Fanconi Anemia (FA...

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Institution:
University of Oxford
Research group:
Martin Cohn
Oxford college:
Oriel College
Department:
Medical Sciences Division - Biochemistry

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2012
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
URN:
uuid:4847b17e-e48c-4b3d-9b3c-9f6320d1d6df
Local pid:
ora:6786
Language:
English
Keywords:
Subjects:

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