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Immunocytochemical study of the dorsal and median raphe nuclei in patients with Alzheimer's disease prospectively assessed for behavioural changes.

Abstract:

The dorsal and median raphe nuclei were examined with immunocytochemistry to display the 5-HT neurones in 16 cases of post-mortem-proven Alzheimer's disease (AD) and 12 age and sex-matched controls. The AD cases had been prospectively assessed during life for expression of behavioural changes as well as for cognitive decline. A significant (P < 0.001) 41% reduction in density of dorsal raphe neurones was found along with a significant (P < 0.02) 29% reduction in density of median raphe ...

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Publication status:
Published

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Authors


Eastwood, SL More by this author
McDonald, B More by this author
Francis, PT More by this author
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Journal:
Neuropathology and applied neurobiology
Volume:
26
Issue:
4
Pages:
347-355
Publication date:
2000-08-05
DOI:
EISSN:
1365-2990
ISSN:
0305-1846
URN:
uuid:48459373-a857-4589-ab09-8371f906ce65
Source identifiers:
242254
Local pid:
pubs:242254

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