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Evolution of the Alx homeobox gene family: parallel retention and independent loss of the vertebrate Alx3 gene.

Abstract:

The Alx gene family is implicated in craniofacial development and comprises two to four homeobox genes in each vertebrate genome analyzed. Using phylogenetics and comparative genomics, we show that the common ancestor of jawed vertebrates had three Alx genes descendent from the two-round genome duplications (Alx1, Alx3, Alx4), compared with a single amphioxus gene. Later in evolution one of the paralogues, Alx3, was lost independently from at least three different vertebrate lineages, whereas...

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Publication status:
Published

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Authors


McGonnell, IM More by this author
Richardson, J More by this author
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Journal:
Evolution and development
Volume:
13
Issue:
4
Pages:
343-351
Publication date:
2011
DOI:
EISSN:
1525-142X
ISSN:
1520-541X
URN:
uuid:484535a3-fee2-466a-9b89-5d171479739c
Source identifiers:
204447
Local pid:
pubs:204447

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