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Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats.

Abstract:

Local adenoviral (Ad)-mediated gene transfer to the carotid artery of the stroke-prone spontaneously hypertensive rat (SHRSP) is successful in improving endothelial function. Here we explored the potential of systemic delivery of Ad encoding endothelial nitric oxide synthase (AdeNOS) to prevent elevation of blood pressure in the SHRSP using both nontargeted and vector targeting approaches. Systemic administration of nontargeted AdeNOS failed to modify the rise in blood pressure in SHRSP when ...

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Publication status:
Published

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Publisher copy:
10.1016/j.ymthe.2005.02.025

Authors


Miller, WH More by this author
Brosnan, MJ More by this author
Morecroft, I More by this author
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Journal:
Molecular therapy : the journal of the American Society of Gene Therapy
Volume:
12
Issue:
2
Pages:
321-327
Publication date:
2005-08-05
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
URN:
uuid:483e1ac7-c59c-4d3e-a94f-d01fdaa45b36
Source identifiers:
104907
Local pid:
pubs:104907

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