- Abstract:
-
Local adenoviral (Ad)-mediated gene transfer to the carotid artery of the stroke-prone spontaneously hypertensive rat (SHRSP) is successful in improving endothelial function. Here we explored the potential of systemic delivery of Ad encoding endothelial nitric oxide synthase (AdeNOS) to prevent elevation of blood pressure in the SHRSP using both nontargeted and vector targeting approaches. Systemic administration of nontargeted AdeNOS failed to modify the rise in blood pressure in SHRSP when ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.ymthe.2005.02.025
-
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- Journal:
- Molecular therapy : the journal of the American Society of Gene Therapy
- Volume:
- 12
- Issue:
- 2
- Pages:
- 321-327
- Publication date:
- 2005-08-05
- DOI:
- EISSN:
-
1525-0024
- ISSN:
-
1525-0016
- URN:
-
uuid:483e1ac7-c59c-4d3e-a94f-d01fdaa45b36
- Source identifiers:
-
104907
- Local pid:
- pubs:104907
- Copyright date:
- 2005
Journal article
Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats.
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