The Influence of HIV Infection on Clinical Presentation, Response to Treatment, and Outcome in Adults with Tuberculous Meningitis

Journal article

BACKGROUND: Tuberculous meningitis occurs more commonly in human immunodeficiency virus (HIV)-infected individuals than in HIV-uninfected individuals, but whether HIV infection alters the presentation and outcome of tuberculous meningitis is unknown. METHODS: We performed a prospective comparison of the presenting clinical features and response to treatment in 528 adults treated consecutively for tuberculous meningitis (96 were infected with HIV and 432 were uninfected with HIV) in 2 tertiar...

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Authors: Thwaites, G; Bang, N; Dung, N; Quy, H; Do Thi Tuong Oanh

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Oxford University Press
• Journal: Journal of Infectious Diseases
• Issue: 12
• Pages: 2134-2141
• Publication date: 2005-12-15
• Acceptance date: 2005-07-19
• DOI: 10.1086/498220
• EISSN: 1537-6613
• ISSN: 0022-1899
• Pmid: 16288379
• Language: English
• Keywords: Humans; Fever; Recurrence; Anti-Bacterial Agents; Middle Aged; Treatment Outcome; Female; Journal Article; Mycobacterium tuberculosis; Inpatients; Logistic Models; Hospitals; Adolescent; HIV Infections; Aged; Coma; Tuberculosis, Meningeal; Microbial Sensitivity Tests; Research Support, Non-U.S. Gov't; Vietnam; Survival Analysis; Adult; Prospective Studies; Male; Aged, 80 and over; Comparative Study; SBTMR