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Desymmetrization by direct cross-metathesis producing hitherto unreachable P-stereogenic phosphine oxides

Abstract:
Desymmetrization of prochiral di- and trialkenyl phosphine oxides by cross-metathesis with various olefinic partners allowed direct access to novel racemic P-stereogenic products featuring two or three different alkenyl groups. The excellent control of product selectivity and E/Z selectivity allowed the preparation of desymmetrized products in good yields from readily available precursors. These are the first examples of desymmetrization of prochiral substrates by direct cross-metathesis. © 2005 Elsevier Ltd. All rights reserved.
Publication status:
Published

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Publisher copy:
10.1016/j.tet.2005.01.019

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
TETRAHEDRON
Volume:
61
Issue:
9
Pages:
2395-2400
Publication date:
2005-02-28
DOI:
ISSN:
0040-4020
URN:
uuid:482d7e1c-523d-4cfb-837b-7e5c39cd3304
Source identifiers:
52173
Local pid:
pubs:52173
Language:
English
Keywords:

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