Journal article icon

Journal article

Dendritic cell function can be modulated through cooperative actions of TLR ligands and invariant NKT cells.

Abstract:

The quality of signals received by dendritic cells (DC) in response to pathogens influences the nature of the adaptive response. We show that pathogen-derived signals to DC mediated via TLRs can be modulated by activated invariant NKT (iNKT) cells. DC maturation induced in vivo with any one of a variety of TLR ligands was greatly improved through simultaneous administration of the iNKT cell ligand alpha-galactosylceramide. DC isolated from animals treated simultaneously with TLR and iNKT cell...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.4049/jimmunol.178.5.2721

Authors


Expand authors...
Journal:
Journal of Immunology
Volume:
178
Issue:
5
Pages:
2721-2729
Publication date:
2007-03-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
8597
Language:
English
Keywords:
Pubs id:
pubs:8597
UUID:
uuid:481fa542-502d-4c54-91bc-debb34ad6754
Local pid:
pubs:8597
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP