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Dendritic cell function can be modulated through cooperative actions of TLR ligands and invariant NKT cells.

Abstract:

The quality of signals received by dendritic cells (DC) in response to pathogens influences the nature of the adaptive response. We show that pathogen-derived signals to DC mediated via TLRs can be modulated by activated invariant NKT (iNKT) cells. DC maturation induced in vivo with any one of a variety of TLR ligands was greatly improved through simultaneous administration of the iNKT cell ligand alpha-galactosylceramide. DC isolated from animals treated simultaneously with TLR and iNKT cell...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.178.5.2721

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
178
Issue:
5
Pages:
2721-2729
Publication date:
2007-03-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:481fa542-502d-4c54-91bc-debb34ad6754
Source identifiers:
8597
Local pid:
pubs:8597

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