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Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS

Abstract:

Hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopy can measure cardiac pyruvate dehydrogenase (PDH) flux in vivo through 13C-label incorporation into bicarbonate. Using this technology substrate availability as well as pathology have been shown to modulate PDH flux. Clinical protocols attempt to standardize PDH flux with oral glucose loading prior to scanning, while rodents in preclinical studies are usually scanned in the fed state. We aimed to establish which strategy was optima...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/nbm.3992

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Miller, JJ More by this author
Chong, C-R More by this author
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Publisher:
Wiley Publisher's website
Journal:
NMR in Biomedicine Journal website
Volume:
31
Issue:
9
Pages:
e3992
Publication date:
2018-07-24
Acceptance date:
2018-06-07
DOI:
EISSN:
1099-1492
ISSN:
0952-3480
Pubs id:
pubs:859758
URN:
uri:481ae2f6-b16a-4a4c-af86-0555f011a013
UUID:
uuid:481ae2f6-b16a-4a4c-af86-0555f011a013
Local pid:
pubs:859758

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