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Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS

Abstract:

Hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopy can measure cardiac pyruvate dehydrogenase (PDH) flux in vivo through 13C-label incorporation into bicarbonate. Using this technology substrate availability as well as pathology have been shown to modulate PDH flux. Clinical protocols attempt to standardize PDH flux with oral glucose loading prior to scanning, while rodents in preclinical studies are usually scanned in the fed state. We aimed to establish which strategy was optima...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/nbm.3992

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
NMR in Biomedicine Journal website
Volume:
31
Issue:
9
Pages:
e3992
Publication date:
2018-07-24
Acceptance date:
2018-06-07
DOI:
EISSN:
1099-1492
ISSN:
0952-3480
Keywords:
Pubs id:
pubs:859758
UUID:
uuid:481ae2f6-b16a-4a4c-af86-0555f011a013
Local pid:
pubs:859758
Deposit date:
2018-06-29

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